Cannabinoid hyperemesis

Cannabinoid hyperemesis is a condition most likely first identified back in 1926 but not explored further by the medical community.  It came to modern light in 2004 when in South Australia several patients were identified as have something different than normal gastrointestinal problems or psychogenic vomiting.

According to the study published in PUBMED back in 2004 the patients were very chronic cannabis users and that the problem ceased when they stopped taking cannabis.  While the study only included 9 identified people it appears that the data presented is compelling:

The patients would start to profusely vomit, often without warning. Nausea, sweating, colicky abdominal pain, and polydipsia often accompanied these events. Patients would take multiple hot baths or showers in an attempt to quell the hyperemesis. Most attempted to cope at home unless they exhausted their hot water supply or became debilitated by severe vomiting. At this point they would present to hospital for intravenous fluid replacement. Vomiting tended to be intractable and refractory to the spectrum of antiemetic medication.

Given that Cannabis is traditionally knows as being anti-emetic the medical community is at a lose for why this condition exists in some individuals

The reasons for this are obscure. We also have difficulty explaining why, while this disease takes years to develop, it resurfaces within weeks of cannabis resumption, even after considerable periods of abstinence.

given the large number of people who are chronic users of Cannabis this would be considered a minor issue of concern for medical use.

More info can be found on PUBMED – Link

Article PUBMED1774264

In followup studies which cite this originating study there are a number of reports.  Including a treatment for the disorder.

That information can be found here

Cited By – LINK

Successful Treatment of Suspected Cannabinoid Hyperemesis Syndrome Using Haloperidol in the Outpatient Setting – LINKPMC4997062